Bienvenido/a a
Mendel's Garden

el lugar en el que cultivamos nuestro conocimiento

Explora la base genética detrás de la versión 1.0

Rasgos analizados

ESTABILIDAD EMOCIONAL

RESPONSABILIDAD

APERTURA A LA EXPERIENCIA

AMABILIDAD

EXTRAVERSIÓN

EMOCIONES POSITIVAS

APRENDIZAJE DE ERRORES

AGRESIVIDAD

INTELIGENCIA

RENDIMIENTO COGNITIVO

MEMORIA EPISÓDICA

MOVIMIENTO DURMIENDO

SUEÑO PROFUNDO

REFLEJO ESTORNUDO FÓTICO

CONDUCTA FRENTE AL JUEGO

CONSUMO DE ALCOHOL

PREFERENCIA POR AROMA FLORAL

PÉRDIDA AUDITIVA

SENSIBILIDAD AL DOLOR

SENSIBILIDAD AL DOLOR

AGRESIVIDAD

SUEÑO PROFUNDO

MEMORIA EPISÓDICA

PÉRDIDA AUDITIVA

GENES ESTUDIADOS

Aportación de la genética

Genes analizados

XKR6  L3MBTL2  CHADL  SLC6A4  PTPRF  ANO4  SNAP25  CHMP4B  LINC00529-201  AL353595.1  SBF2  CELF4  PAFAH1B1  LINC01811  AL391117.1  LINGO1  RABGAP1L  CHMP3  RASSF1  STAB1  HIST1H2BC  ASCC3  TMEM106B  LMTK2  FAM120A  LRP4  DRD2  DCAF5  CSNK1G1  ZNF646  ZCCHC14  MAPT-AS1  AATK  BAIAP2  TCF4  ZC3H7B  CACNA1E  LINC00461  ERI1  XKR6  LINGO2  

Estudios

Chu, X. (2020). A genome-wide multiphenotypic association analysis identified common candidate genes for subjective well-being, depressive symptoms and neuroticism. Journal of Psychiatric Research, 124, 22–28.

Nagel, M. (2018). Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nature Genetics, 50(7), 920–927.

Luciano, M. (2017). Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. Nature Genetics, 50(1), 6–11.

Vassend, O., & Skrondal, A. (2011). The NEO personality inventory revised (NEO-PI-R): Exploring the measurement structure and variants of the five-factor model. Personality and Individual Differences, 50(8), 1300–1304.

RESPONSABILIDAD

LINC00461  SMOC1  LAMB1  MRPS18C  KATNAL2  DEFB  ZCCHC3  SOX12  NRSN2

Vassend, O., & Skrondal, A. (2011). The NEO personality inventory revised (NEO-PI-R): Exploring the measurement structure and variants of the five-factor model. Personality and Individual Differences, 50(8), 1300–1304.

Zajenkowski, M. (2015). Is conscientiousness positively or negatively related to intelligence? Insights from the national level. Learning and Individual Differences, 43, 199–203.

de Moor, M. H. M. Terraciano (2010). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17(3), 337–349.

Amin, N. (2012). A genome-wide linkage study of individuals with high scores on NEO personality traits. Molecular Psychiatry, 17(10), 1031–1041.

APERTURA A LA EXPERIENCIA

ZNF180  FUNDC1  CREBL2  CLNK TSPAN13  RASA1  PDIA6  KCNF1  ELAVL2  TUSC1  FAM169B  IGF1R  FLI1  KCNJ1  LILRA4  LAIR1  

Amin, N. (2012). Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. European Journal of Human Genetics, 21(8), 876–882.

Vassend, O., & Skrondal, A. (2011). The NEO personality inventory revised (NEO-PI-R): Exploring the measurement structure and variants of the five-factor model. Personality and Individual Differences, 50(8), 1300–1304.

AMABILIDAD

THUMPD2  CLOCK  CDH13  BFSP2  AVP  SPCS3  VEGFC

Bae, H. T. (2013). Genome-Wide Association Study of Personality Traits in the Long Life Family Study. Frontiers in Genetics, 4.

EXTRAVERSIÓN

GBE1   MTMR9  FAM167A  PCDH15  WSCD2  RBFOX1  BDNF  ZNF180  CDH23  CDH13  DAPK1  DRD4  OLFM1  KIAA0649  CRTAC1  LOXL4  PYROXD2  GRIA4

Vassend, O., & Skrondal, A. (2011). The NEO personality inventory revised (NEO-PI-R): Exploring the measurement structure and variants of the five-factor model. Personality and Individual Differences, 50(8), 1300–1304.

Zajenkowski, M. (2015). Is conscientiousness positively or negatively related to intelligence? Insights from the national level. Learning and Individual Differences, 43, 199–203.

de Moor, M. H. M. Terraciano (2010). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17(3), 337–349.

Amin, N. (2012). A genome-wide linkage study of individuals with high scores on NEO personality traits. Molecular Psychiatry, 17(10), 1031–1041.

EMOCIONES POSITIVAS

LINC01221

Wingo, A. P. (2016). Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs. Molecular Psychiatry, 22(5), 774–783.

APRENDIZAJE DE ERRORES

ANKK1

Bravo A, Crickmore N, Gould F, Heckel DG, Rie J Van, Dennehy TJ, et al. “ Y. 2007;318(December). Klein, T. A., Neumann, J., Reuter, M., Hennig, J., von Cramon, D. Y., & Ullsperger, M. (2007). Genetically Determined Differences in Learning from Errors. Science, 318(5856), 1642–1645.

AGRESIVIDAD

MAOA  SLC6A4  CDH13  SPIN1  PRUNE2  AC105399  LRRTM4  LINC00951  FLT3  LINC01122  FPR3  CSMD3  PTPRU

Tiihonen, J. (2014). Genetic background of extreme violent behavior. Molecular Psychiatry, 20(6), 786–792.

INTELIGENCIA

PEF1  ST3GAL3  RP11-424D14.1  TTLL7  MIR137HG  COL11A1  ATXN7L2  GATAD2B  CACNA1E  IPO9-AS1  KLHL29  LRPPRC  SIX3  NRXN1  BCL11A  LINC01104  THSD7B  RBMS1  DPP4  RPL7P61  TTC21B  ZNF385B  PLCL1  SATB2-AS1  C2orf57  NR1D2  ARPP21  CACNA2D2  NT5DC2  FOXP1  CADM2  RNU6-488P  MYH15  RNA5SP142  CLSTN2  PCGF3  FAM193A  TAPT1-AS1  NCAPG  ANAPC4  RP11-707A18.1  RNU6-699P  GRID2  STPG2  SLC39A8  RN7SL89P  TTC29  PET112  ADCY2  CDH9  PLK2  PDE4D  RP11-2O17.2  SREK1IP1  FBXL17  MAN2A1  STARD4-AS1  CTB-131B5.5  DOCK2  DBN1  SLC22A23  MCUR1  CDKAL1  CASC15  RPSAP2  MYO6  POU3F2  RPS4XP9  ARID1B  GLCCI1  RNA5SP228  ZMIZ2  AUTS2  CALN1  CALU  EXOC4  SGCZ  WRN  CTD-3025N20.2  TSNARE1  LRRC14  SUMO2P2  ELAVL2  HABP4  JMJD1C  MGEA5  GBF1  SORCS3  PITPNM2  SNORA25  CKB  HNRNPA1P48  RBL2  DCC  MAST3  ARFGEF2  RPL23AP12  TAB1

Savage, J.E., et al. (2018) Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet 50, 912–919.

RENDIMIENTO COGNITIVO

SLC39A8  OGA  RBL2  ANAPC4  BCL11A  SEPTIN3  LOC101929719  ATXN7L2  PEF1  ZMIZ2  GATB LOC107986197  TSNARE1  ELAVL2  FAM193A  CALU  GATAD2B  MGAT3 MGAT3-AS1  SREK1IP1  SGCZ  STAB1  GBF1 

Lee, J. J. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50(8), 1112–1121.

MEMORIA EPISÓDICA

FASTKD2

Tulving E (2010). “Précis of Elements of episodic memory”. Behavioral and Brain Sciences. 7 (2): 223–238.

MOVIMIENTO DURMIENDO

BTBD9  RANBP17  LMO1  STK33  MICALL2  LINC02086  LINC01478  LINC02520  LINC01812  MAP2K5  PTPRD  MEIS1  RPL35P8  GSTO3P  RN7SKP212  CASC16  HELLPAR  DPH6-DT

Kripke, D. F. (2015). Genetic variants associated with sleep disorders. Sleep Medicine, 16(2), 217–224.

Moore, H. (2014). Periodic Leg Movements during Sleep Are Associated with Polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep, 37(9), 1535–1542.

Stockman, J. (2009). A Genetic Risk Factor for Periodic Limb Movements in Sleep. Yearbook of Pediatrics, 2009, 337–338.

Haba-Rubio, J. (2015). Prevalence and determinants of periodic limb movements during sleep in the general population: The HypnoLaus study. Sleep Medicine, 16, S350.

Thireau, J. (2017). MEIS1 variant as a determinant of autonomic imbalance in Restless Legs Syndrome. Scientaific Reports, 7(1).

SUEÑO PROFUNDO

ADA

Bachmann, V. (2011). Functional ADA Polymorphism Increases Sleep Depth and Reduces Vigilant Attention in Humans. Cerebral Cortex, 22(4), 962–970.

REFLEJO ESTORNUDO FÓTICO

NR2F2  CADM2  LINC02025

Wang, M. (2019). A genome-wide association study on photic sneeze reflex in the Chinese population. Scientific Reports, 9(1).

Sasayama, D. (2018). A genome-wide association study on photic sneeze syndrome in a Japanese population. Journal of Human Genetics, 63(6), 765–768.

Eriksson, N. (2010). Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits. PLoS

CONDUCTA FRENTE AL JUEGO

VLDLR-AS1  ATXN1  

Lind, P. A. (2012). Genome-wide association study of a quantitative disordered gambling trait. Addiction Biology, 18(3), 511–522.

CONSUMO DE ALCOHOL

ADH1B  GCKR  SLC39A8  SERPINA1  TNFSF12–13

Liu, M. (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51(2), 237–244.

le Strat, Y., Ramoz, N., Pickering, P., Burger, V., Boni, C., Aubin, H. J., Adès, J., Batel, P., & Gorwood, P. (2007). The 3′ Part of the Dopamine Transporter Gene DAT1/SLC6A3 Is Associate

PREFERENCIA POR AROMA FLORAL

OR5A1 

Keller, A. (2007). Genetic variation in a human odorant receptor alters odour perception. Nature, 449(7161), 468–472.

PÉRDIDA AUDITIVA

SIK3

Wolber, L. E. (2014). Salt-inducible kinase 3, SIK3, is a new gene associated with hearing. Human Molecular Genetics, 23(23), 6407–6418.

SENSIBILIDAD AL DOLOR

SCN9A SCN1A-AS1

Valdes, A. (2010). Pain perception is altered by a nucleotide polymorphism in SCN9A. Yearbook of Medicine, 2010, 20–21.